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Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation.

Archive ouverte | Urayama, Kyoji | CCSD

OBJECTIVE: Identification of novel factors that contribute to myocardial repair and collateral vessel growth hold promise for treatment of heart diseases. We have shown that transient prokineticin receptor-1 (PKR1) gene transfer p...

Transgenic myocardial overexpression of prokineticin receptor-2 (GPR73b) induces hypertrophy and capillary vessel leakage.

Archive ouverte | Urayama, Kyoji | CCSD

International audience. AIMS: Prokineticins are small secreted bioactive molecules. They exert their biological activity by binding to two G protein-coupled receptors. Previously, we have shown that the overexpressi...

The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesis.

Archive ouverte | Urayama, Kyoji | CCSD

Prokineticins are potent angiogenic factors that bind to two G protein-coupled receptors to initiate their biological effects. We hypothesize that prokineticin receptor-1 (PKR1/GPR73) signaling may contribute to cardiomyocyte surv...

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