Afficher la couverture 'Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells | Hajj, Joëlle, El' en grand format
/5

0 avis

Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells

Archive ouverte

Hajj, Joëlle, El | Nguyen, Eric | Liu, Qingyuan | Bouyer, Claire | Adriaenssens, Eric | Hilal, George | Ségal-Bendirdjian, Evelyne

Edité par CCSD ; BioMed Central -

International audience. Background: Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators. Retinoids are well-known inducers of granulocytic maturation associated with hTERT repression in acute promyelocytic leukemia (APL) blasts. In a maturation-resistant APL cell line, we have previously identified a new pathway of retinoid-induced hTERT transcriptional repression independent of differentiation. Furthermore, we reported the isolation of a cell variant resistant to this repression. Those cell lines could serve as unique tools to identify new telomerase regulators.

Suggestions

Du même auteur

Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells

Archive ouverte | El Hajj, Joëlle | CCSD

International audience. Background: Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase...

WT1 expression is inversely correlated with MYCNamplification or expression and associated with poor survival innon-MYCN-amplified neuroblastoma

Archive ouverte | Masserot, Caroline | CCSD

International audience. Neuroblastoma (NB) is the most common extra cranial solid tumor in childhood and the most frequently diagnosed neoplasm during infancy. A striking feature of this tumor is its clinical hetero...

Complex context relationships between DNA methylation and accessibility, histone marks, and hTERT gene expression in acute promyelocytic leukemia cells: perspectives for all‐ trans retinoic acid in cancer therapy

Archive ouverte | Garsuault, Delphine | CCSD

International audience. Telomerase (hTERT) reactivation and sustained expression is a key event in the process of cellular transformation. Therefore, the identification of the mechanisms regulating hTERT expression ...

Chargement des enrichissements...