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Ultrabright and Fluorogenic Probes for Multicolor Imaging and Tracking of Lipid Droplets in Cells and Tissues.

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Collot, Mayeul | Fam, Kyong Tkhe | Ashokkumar, Pichandi | Faklaris, Orestis | Galli, Thierry | Danglot, Lydia | Klymchenko, Andrey, S

Edité par CCSD ; American Chemical Society -

Supporting information : librement accessible sur le site de l'éditeur à l'adresse suivante : https://pubs.acs.org/doi/suppl/10.1021/jacs.7b12817. International audience. Lipid droplets (LDs) are intracellular lipid-rich organelles that regulate the storage of neutral lipids and were recently found to be involved in many physiological processes, metabolic disorders, and diseases including obesity, diabetes, and cancers. Herein we present a family of new fluorogenic merocyanine fluorophores based on an indolenine moiety and a dioxaborine barbiturate derivative. These so-called StatoMerocyanines (SMCy) fluoresce from yellow to the near-infrared (NIR) in oil with an impressive fluorescence enhancement compared to aqueous media. Additionally, SMCy display remarkably high molar extinction coefficients (up to 390 000 M

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