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JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells

Archive ouverte | Lawson, Hannah | CCSD

International audience. Abstract Lifelong multilineage hematopoiesis critically depends on rare hematopoietic stem cells (HSCs) that reside in the hypoxic bone marrow microenvironment. Although the role of the canon...

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions

Archive ouverte | Guitart, Amelie, V | CCSD

International audience. Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the ...

CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation

Archive ouverte | Lawson, Hannah | CCSD

International audience. Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic differentiation hierarchy and sustain multilineage hematopoiesis. Here, we show that the transcriptional regulator CITE...

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