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Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena

Archive ouverte | Suhren, Jan | CCSD

International audience. RNAi-mediated positive feedback loops are pivotal for the maintenance of heterochromatin, but how they are downregulated at heterochromatin-euchromatin borders is not well understood. In the ...

Small RNA-Mediated trans -Nuclear and trans -Element Communications in Tetrahymena DNA Elimination

Archive ouverte | Noto, Tomoko | CCSD

International audience. Epigenetic inheritance of acquired traits is widespread among eukaryotes, but how and to what extent such information is transgenerationally inherited is still unclear. The patterns of progra...

A SUMO E3 ligase promotes long non-coding RNA transcription to regulate small RNA-directed DNA elimination

Archive ouverte | Shehzada, Salman | CCSD

International audience. Small RNAs target their complementary chromatin regions for gene silencing through nascent long non-coding RNAs (lncRNAs). In the ciliated protozoan Tetrahymena , the interaction between Piwi...

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