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Oral Supplementation Effect Of Iron And Its Complex Form With Quercetin On Oxidant Status And On Redistribution Of Essential Metals In Organs Of Streptozotocin Diabetic Rats

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Berroukeche, Farid | Mokhtari-Soulimane, Nassima | Imessaoudene, Asmahan | Sabri, Ahmed | Ronot, Pascale | Boos, Anne | Belhandouz, Amina | Merzouk, Hafida | Elhabiri, Mourad

Edité par CCSD ; ILEX PUBLISHING HOUSE -

International audience. Background and aims: Quercetin, is a polyphenolic antioxidant compound. It is able toform complex with metal ions such as iron and exerts a broad range of biologicalactivities like improving metabolic disorders. This research aims at investigating theeffect of oral supplementation of iron (2.5mg Fe/Kg/day) and its complex form (molarratio 1:5; 2.5mg/25mg/Kg/day) with quercetin (25mg/Kg/day) on lipid metabolism,oxidant status and trace elements contents in organs of Wistar diabetic rats (45mg/kg/rat.ip of streptozotocin) during eight weeks of experimentation. Material andmethod: To achieve this, liver and adipose tissue enzymes activities, NO•, O2-•, TBARs,carbonyl protein levels in plasma were analysed. Metals (Cu, Fe, Mg, Zn) analysis oforgans were determined by inductively coupled plasma atomic emission spectroscopy.Results: Iron supplemented alone induced a noticeable disorder in lipid, lipoprotein,lipases and oxidant status. Yet, it caused an imbalance in the redistribution of metals inthe organs of diabetic and non diabetic rats. Iron-quercetin complex was shown as lessharmful and more beneficial than iron supplemented alone. Conclusions: This complexcould reverse oxidative stress and iron deficiency mostly caused by the diabetic diseasebut at the same time it induces an imbalance in redistribution of other essential metals.

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