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Drug resistance‑related sunitinib sequestration in autophagolysosomes of endothelial cells

Archive ouverte | Wu, Shuang | CCSD

International audience. Our previous study demonstrated that the tyrosine kinase receptor inhibitor sunitinib induces acquired drug resistance in endothelial cells. The present study explored the role of lysosomal s...

Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines.

Archive ouverte | Gest, Caroline | CCSD

International audience. BACKGROUND: Rho GTPases are involved in cellular functions relevant to cancer. The roles of RhoA and Rac1 have already been established. However, the role of Rac3 in cancer aggressiveness is ...

Cross-drug resistance to sunitinib induced by doxorubicin in endothelial cells

Archive ouverte | Huang, Limin | CCSD

International audience. Multiple drug resistance remains an unsolved problem in cancer therapy. A previous study has demonstrated that the chemotherapeutic drug doxorubicin (Dox) induced upregulation of P-glycoprote...

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