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Limitations of IL-2 and Rapamycin in Immunotherapy of Type 1 Diabetes

Archive ouverte | Baeyens, Audrey | CCSD

International audience. Administration of low-dose interleukin-2 (IL-2) alone or combined with rapamycin (RAPA) prevents hyperglycemia in NOD mice. Also, low-dose IL-2 cures recent-onset type 1 diabetes (T1D) in NOD...

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Archive ouverte | Gonzalo Núñez, Nicolas | CCSD

International audience. Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates with poor prognosis and is associated with local immunosuppression, which can be partly mediated by r...

Role of Cytokines in Thymus- Versus Peripherally Derived-Regulatory T Cell Differentiation and Function

Archive ouverte | Goldstein, Jérémie David | CCSD

International audience. CD4 + CD25 + Foxp3 + regulatoryT cells (Tregs) are essential players in the control of immune responses. Recently, accordingly to their origin, two main subsets of Tregs have been described: ...

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