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CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

Archive ouverte | Jeffery, Daniel | CCSD

International audience. Tumour evolution is driven by both genetic and epigenetic changes. CENP-A, the centromeric histone H3 variant, is an epigenetic mark that directly perturbs genetic stability and chromatin whe...

CENP-A overexpression drives distinct cell fates depending on p53 status. La surexpression CENP-A entraîne des destins cellulaires distincts en fonction du statut p53

Archive ouverte | Jeffery, Daniel | CCSD

Tumour evolution is driven by both genetic and epigenetic changes. CENP-A, the centromeric histone H3 variant, is an epigenetic mark that directly perturbs genetic stability and chromatin when overexpressed. Although CENP-A overex...

Chromatin plasticity: A versatile landscape that underlies cell fate and identity

Archive ouverte | Yadav, Tejas | CCSD

International audience. During development and throughout life, a variety of specialized cells must be generated to ensure the proper function of each tissue and organ. Chromatin plays a key role in determining cell...

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