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AIF loss deregulates hematopoiesis and reveals different adaptive metabolic responses in bone marrow cells and thymocytes

Archive ouverte | Cabon, Lauriane | CCSD

International audience. Mitochondrial metabolism is a tightly regulated process that plays a central role throughout the lifespan of hematopoietic cells. Herein, we analyze the consequences of the mitochondrial oxid...

Mitochondrial AIF Loss Causes Metabolic Reprogramming, Caspase-Independent Cell Death Blockade, Embryonic Lethality, and Perinatal Hydrocephalus

Archive ouverte | Delavallée, Laure | CCSD

International audience. Objectives: Apoptosis-Inducing Factor (AIF) is a protein involved in mitochondrial electron transport chain assembly/stability and in programmed cell death. The relevant role of this protein ...

Influence of mitochondrial metabolism in hematopoieisis : Analysis of the adaptative response of bone marrow cells and thymocytes to OXPHOS dysfunction. Influence du métabolisme mitochondrial dans l'hématopoïèse : Analyse de la réponse adaptative des cellules de la moelle osseuse et des thymocytes au dysfonctionnement de l’OXPHOS

Archive ouverte | Bertaux, Audrey | CCSD

By integrating different biochemical pathways and generating energy in form of ATP, through the electron transfer associated to oxidative phosphorylation (OXPHOS), mitochondria play a key role in cellular metabolism. In the hemato...

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