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Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.

Archive ouverte | Le Rouzic, Erwann | CCSD

International audience. BACKGROUND: LEDGF/p75 (LEDGF) is the main cellular cofactor of HIV-1 integrase (IN). It acts as a tethering factor for IN, and targets the integration of HIV in actively transcribed gene regi...

Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration

Archive ouverte | Bonnard, Damien | CCSD

International audience

Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase

Archive ouverte | Bonnard, Damien | CCSD

HIV-1 integrase-LEDGF allosteric inhibitors (INLAIs) share the binding site on the viral protein with the host factor LEDGF/p75. These small molecules act as molecular glues promoting hyper-multimerization of HIV-1 IN protein to s...

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