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Environmental cues from neural crest derivatives act as metastatic triggers in an embryonic neuroblastoma model

Archive ouverte | Ben Amar, Dounia | CCSD

International audience. Abstract Embryonic malignant transformation is concomitant to organogenesis, often affecting multipotent and migratory progenitors. While lineage relationships between malignant cells and the...

Iterative inhibition of commissural growth cone exploration, not post-crossing barrier, ensures forward midline navigation through SlitC-PlxnA1 signaling

Archive ouverte | Ducuing, Hugo | CCSD

Sensitization to Slits and Semaphorin (Sema)3B floor plate repellents after midline crossing is thought to be the mechanism expelling commissural axons contralaterally and preventing their back-turning. We studied the role of Slit...

PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments

Archive ouverte | Delloye-Bourgeois, Céline | CCSD

International audience. Robo-Slit and Plexin-Semaphorin signaling participate in various developmental and pathogenic processes. During commissural axon guidance in the spinal cord, chemorepulsion by Semaphorin3B an...

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