The preliminary solution structure of human p13 MTCPI an oncogenic protein encoded by the MTCPI gene, using 2D homonuclear NMR

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The preliminary solution structure of human p13 MTCPI an oncogenic protein encoded by the MTCPI gene, using 2D homonuclear NMR

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International audience. The human oncogenic protein p13 is coded by the gene M T C P I which is expressed on mature prolymphocytic leukemias. We investigate its 3D structure using 2D homonuclear NMR. The main secondary structure elements found in p l3MTCPI are antiparallel 13-sheets which fold in an eight-stranded orthogonal B-barrel. Keywords : 2D NMR-Protein Structure-Molecular Modelisation-Leukemias.

Langue: en

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