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Rare variants and exomes analyses : the example of Early-Onset Alzheimer Disease. Variants rares et analyse d'exomes : application à la maladie d'Alzheimer du sujet jeune

Archive ouverte | Le Guennec, Kilan | CCSD

Next-generation sequencing allows studying and analyzing the genetic component part of complexdiseases mediated by rare variants. However, their interpretation represents a major challenge.Indeed, the sequencing of thousands of ex...

Contribution to Alzheimer's disease risk of rare variants in TREM_2, SORL_1, and ABCA_7 in 1779 cases and 1273 controls

Archive ouverte | Bellenguez, Céline | CCSD

International audience. We performed whole-exome and whole-genome sequencing in 927 late-onset Alzheimer disease (LOAD) cases, 852 early-onset AD (EOAD) cases, and 1273 controls from France. We assessed the evidence...

ABCA7 rare variants and Alzheimer disease risk

Archive ouverte | Le Guennec, Kilan | CCSD

International audience. OBJECTIVE: To study the association between ABCA7 rare coding variants and Alzheimer disease (AD) in a case-control setting. METHODS: We conducted a whole exome analysis among 484 French pati...

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