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NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

Archive ouverte | Armstrong, Florence | CCSD

International audience. Abstract Understanding the pathways that regulate the human T-cell acute lymphoblastic leukemia (T-ALL) initiating cells (T-LiC) activity has been hampered by the lack of biologic assays in w...

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

Archive ouverte | Kusy, Sophie | CCSD

International audience

Interleukin-18 produced by bone marrow- derived stromal cells supports T-cell acute leukaemia progression

Archive ouverte | Uzan, Benjamin | CCSD

International audience. Development of novel therapies is critical for T-cell acute leukae-mia (T-ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T-ALL cell growth. Unexpectedly, MEK...

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