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Protein arginine methylation in lymphocyte signaling

Archive ouverte | Blanchet, Fabien P. | CCSD

International audience. Methylation of arginine is an additional option within the repertoire of post-translational modifications that proteins utilize for their communication with other partner proteins and nucleic...

CD28 costimulatory signal induces protein arginine methylation in T cells

Archive ouverte | Blanchet, Fabien | CCSD

International audience. Protein phosphorylation initiates signal transduction that triggers lymphocyte activation. However, other posttranslational modifications may contribute to this process. Here, we show that CD...

A Novel Biallelic LCK Variant Resulting in Profound T-Cell Immune Deficiency and Review of the Literature

Archive ouverte | Lanz, Anna-Lisa | CCSD

International audience. Abstract Lymphocyte-specific protein tyrosine kinase (LCK) is an SRC-family kinase critical for initiation and propagation of T-cell antigen receptor (TCR) signaling through phosphorylation o...

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