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Modulators of vesicular glutamate transporters : development of pharmacological and diagnostic tools for Alzheimer's disease. Modulateurs du transport vésiculaire du glutamate : développement d’outils pharmacologiques et de diagnostic pour la maladie d’Alzheimer

Archive ouverte | Favre-Besse, Franck-Cyril | CCSD

Vesicular glutamate transporters (VGLUTs) are involved in the recapture and storage of glutamate from cytol to secretory synaptic vesicules. Since their recent characterization in 2000, their implication in several neurodegenerati...

LSP5-2157 a new inhibitor of vesicular glutamate transporters

Archive ouverte | Poirel, Odile | CCSD

International audience. Vesicular glutamate transporters (VGLUT1-3) mediate the uptake of glutamate into synaptic vesicles. VGLUTs are pivotal actors of excitatory transmission and of almost all brain functions. The...

Characterization of a Human Point Mutation of VGLUT3 (p.A211V) in the Rodent Brain Suggests a Nonuniform Distribution of the Transporter in Synaptic Vesicles

Archive ouverte | Ramet, Lauriane | CCSD

International audience. The atypical vesicular glutamate transporter type 3 (VGLUT3) is expressed by subpopulations of neurons using acetylcholine, GABA, or serotonin as neurotransmitters. In addition, VGLUT3 is exp...

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