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Expanding heterochromatin reveals discrete subtelomeric domains delimited by chromatin landscape transitions

Archive ouverte | Hocher, Antoine | CCSD

International audience. The eukaryotic genome is divided into chromosomal domains of heterochromatin and euchromatin. Transcriptionally silent heterochromatin is found at subtelomeric regions, leading to the telomer...

The Crohn’s disease-related bacterial strain LF82 assembles biofilm-like communities to protect itself from phagolysosomal attack

Archive ouverte | Prudent, Victoria | CCSD

International audience. Patients with Crohn’s disease exhibit abnormal colonization of the intestine by adherent invasive E. coli (AIEC). They adhere to epithelial cells, colonize them and survive inside macrophages...

Exogenous chromosomes reveal how sequence composition drives chromatin assembly, activity, folding and compartmentalization

Archive ouverte | Chapard, Christophe | CCSD

v3, 31 octobre 2023. Genomic sequences co-evolve with DNA-associated proteins to ensure the multiscale folding of long DNA molecules into functional chromosomes. In eukaryotes, different molecular complexes organize...

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