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Chromatin remodelling by INO80 at promoter proximal pause sites promotes premature termination of mRNA synthesis

Archive ouverte | Luzzi, Sara | CCSD

Abstract How co-transcriptional RNA quality control is regulated remains poorly understood. Here, we report that in S. cerevisiae premature transcription termination of mRNAs is regulated by the evolutionarily conserved ATP-depend...

Architectural Mediator subunits are differentially essential for global transcription in Saccharomyces cerevisiae

Archive ouverte | Tourigny, Jason | CCSD

International audience. Abstract Mediator is a modular coactivator complex involved in the transcription of the majority of RNA polymerase II-regulated genes. However, the degrees to which individual core subunits o...

Mediator Is Essential for Small Nuclear and Nucleolar RNA Transcription in Yeast

Archive ouverte | Tourigny, Jason | CCSD

International audience. Eukaryotic RNA polymerase II (RNAPII) transcribes mRNA genes and non-protein-coding RNA (ncRNA) genes, including those encoding small nuclear and nucleolar RNAs (sn/snoRNAs). In metazoans, RN...

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