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Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture

Archive ouverte | Eychenne, Thomas | CCSD

International audience. Mediator is a large coregulator complex conserved from yeast to humans and involved in many human diseases, including cancers. Together with general transcription factors, it stimulates prein...

Mediator independently orchestrates multiple steps of preinitiation complex assembly in vivo

Archive ouverte | Eyboulet, Fanny | CCSD

International audience. Mediator is a large multiprotein complex conserved in all eukaryotes, which has a crucial coregulator function in transcription by RNA polymerase II (Pol II). However, the molecular mechanism...

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Archive ouverte | Carrière, Lucie | CCSD

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