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Nanoscale architecture of a VAP-A-OSBP tethering complex at membrane contact sites

Archive ouverte | de La Mora, Eugenio | CCSD

International audience. Membrane contact sites (MCS) are subcellular regions where two organelles appose their membranes to exchange small molecules, including lipids. Structural information on how proteins form MCS...

La cryo-microscopie électronique nous révèle une nouvelle vision de la cellule et de ses composants

Archive ouverte | Lévy, Daniel | CCSD

International audience. Cryo-electron microscopy (cryo-EM) is a technique for imaging biological samples that plays a central role in structural biology, with high impact on research fields such as cell and developm...

VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites

Archive ouverte | Subra, Mélody | CCSD

International audience. Membrane contact sites (MCSs) are heterogeneous in shape, composition, and dynamics. Despite this diversity, VAP proteins act as receptors for multiple FFAT motif-containing proteins and driv...

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