Subspecific origin and haplotype diversity in the laboratory mouse

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Yang, Hyuna | Wang, Jeremy | Didion, John, P. | Buus, Ryan, J. | Bell, Timothy, A. | Welsh, Catherine, E. | Bonhomme, François | Yu, Alex Hon-Tsen | Nachman, Michael, W. | Pialek, Jaroslav | Tucker, Priscilla | Boursot, Pierre | Mcmillan, Leonard | Churchill, Gary, A. | de Villena, Fernando Pardo-Manuel

Edité par CCSD ; Nature Publishing Group -

International audience. Here we provide the first genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild caught mice from three subspecies of Mus musculus. We demonstrate that classical laboratory strains are derived from a few fancy mice with limited haplotype diversity. Their genomes are overwhelmingly M. m. domesticus in origin and the remainder is mostly of Japanese origin. We generated genome-wide haplotype maps based on identity by descent from fancy mice and demonstrate that classical inbred strains have limited and non-randomly distributed genetic diversity. In contrast, wild-derived laboratory strains represent a broad sampling of diversity Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

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