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aPKCi Triggers Basal Extrusion of Luminal Mammary Epithelial Cells by Tuning Contractility and Vinculin Localization at Cell Junctions

Archive ouverte | Villeneuve, Clémentine | CCSD

International audience. Metastasis is the main cause of cancer-related deaths. How a single oncogenic cell evolves within highly organized epithelium is still unknown. Here, we found that the overexpression of the p...

A new pipeline for pathophysiological analysis of the mammary gland based on organoid transplantation and organ clearing

Archive ouverte | Lagoutte, Emilie | CCSD

International audience. Recent developments in techniques for tissue clearing and size reduction have enabled optical imaging of whole organs and the study of rare tumorigenic events in vivo The adult mammary gland ...

A new approach to measure forces at junction vertices in an epithelium

Archive ouverte | Goud, Bruno | CCSD

Abstract The mechanical properties of cell-cell junctions are critical for the stability of an epithelium. Cell-cell junction ablation experiments are classically used as a readout for junctional mechanics. However, without the kn...

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