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The development of brain magnetic resonance approaches in large animal models for preclinical research

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Ella, Arsène | Barrière, David, A | Adriaensen, Hans | Palmer, David | Melzer, Tracy, R | Mitchell, Nadia, L | Keller, Matthieu

Edité par CCSD ; American Society of Animal Science -

International audience. Magnetic resonance imaging is a very powerful ap-proach to perform anatomical and functional imaging explorations. Large animal models are perfectly suited for MRI studies using clinical devices and these tools are cur-rently being developed and improved. Here we highlight an example of MRI to demonstrate the efficacy of gene therapy in sheep models of Batten disease, a pediatric neurodegenerative disease.

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