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Nanopore Sequencing as a Cutting-Edge Technology for Medulloblastoma Classification

Archive ouverte | Filser, Mathilde | CCSD

International audience. Background: Medulloblastoma (MB) is one of the most prevalent embryonal malignant brain tumors. Current classification organizes these tumors into four molecular subgroups (WNT, SHH, Group 3,...

Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups

Archive ouverte | Lobón-Iglesias, María-Jesús | CCSD

International audience. Abstract Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, suggesting diverse lineages of origin. Here, we investigate the imaging of human ATRT at diagnos...

An autocrine ActivinB mechanism drives TGF β/Activin signaling in Group 3 medulloblastoma

Archive ouverte | Morabito, Morgane | CCSD

International audience. Medulloblastoma (MB) is a pediatric tumor of the cerebellum divided into four groups. Group 3 is of bad prognosis and remains poorly characterized. While the current treatment involving surge...

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