Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils

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Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils

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Edité par CCSD ; Rockefeller University Press -

International audience. Running title : actomyosin contractility maintains neutrophil nuclear integrity eTOCBowes et al. show that in zebrafish embryos deficient in the cofilin cofactor AIP1/Wdr1, neutrophils display F-actin as cytoplasmic aggregates, spatially uncoupled from active myosin, then a progressive unwinding of their nucleus, followed by eruptive cell death. This adverse phenotype is fully rescued by depletion of another cofilin cofactor, coronin 1A.

Langue: en

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