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Elastin-Derived Peptides Induce a T-Helper Type 1 Polarization of Human Blood Lymphocytes

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Debret, Romain | Antonicelli, Frank | Theill, Aurore | Hornebeck, William | Bernard, Philippe | Guenounou, Moncef | Le Naour, Richard

Edité par CCSD ; American Heart Association -

International audience. Increased level of elastin-derived peptides (EDPs) is observed in the serum of patients with manifestations of arterial diseases. We here investigated whether EDPs might exert, at systemic level, a regulatory role for the T-helper type 1 (Th-1)/Th-2 cellular immune response by human peripheral blood lymphocytes (PBLs) expressing the spliced-galactosidase (S-gal)-elastin receptor.

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