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ARF promotes the degradation of the Epidermal Growth Factor Receptor by the lysosome

Archive ouverte | Beaumont, Anaïs | CCSD

International audience. Epidermal Growth Factor Receptor (EGFR) signaling regulates multiple cellular processes including proliferation , survival and apoptosis, and is attenuated by lysosomal receptor degradation. ...

Nuclear translocation of IGF1R by intracellular amphiregulin contributes to the resistance of lung tumour cells to EGFR-TKI

Archive ouverte | Guerard, Marie | CCSD

International audience. Many Receptor Tyrosine Kinases translocate from the cell surface to the nucleus in normal and pathological conditions, including cancer. Here we report the nuclear expression of insulin-like ...

Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy

Archive ouverte | Abou-Fayçal, Cherine | CCSD

International audience. Receptor tyrosine kinases (RTKs) belong to a family of transmembrane receptors that display tyrosine kinase activity and trigger the activation of downstream signalling pathways mainly involv...

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