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Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

Archive ouverte | Danis, Clément | CCSD

Tau proteins aggregate into filaments in brain cells in Alzheimer’s disease and related disorders referred to as tauopathies. Here, we used fragments of camelid heavy-chain-only antibodies (VHHs or single domain antibody fragments...

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

Archive ouverte | Danis, Clément | CCSD

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Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein

Archive ouverte | Mortelecque, Justine | CCSD

Abstract The use of VHHs (Variable domain of the Heavy-chain of the Heavy-chain-only antibodies) as disease-modifying biomolecules in neurodegenerative disorders holds promises including to target aggregation-sensitive proteins. E...

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