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Conformational changes in p47 phox upon activation highlighted by mass spectrometry coupled to hydrogen/deuterium exchange and limited proteolysis

Archive ouverte | Marcoux, Julien | CCSD

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p47 phox Molecular Activation for Assembly of the Neutrophil NADPH Oxidase Complex

Archive ouverte | Marcoux, Julien | CCSD

International audience. The p47phox cytosolic factor from neutrophilic NADPH oxidase has always been resistant to crystallogenesis trials due to its modular organization leading to relative flexibility. Hydrogen/deu...

Alteration of the langerin oligomerization state affects Birbeck granule formation.

Archive ouverte | Chabrol, Eric | CCSD

International audience. Langerin, a trimeric C-type lectin specifically expressed in Langerhans cells, has been reported to be a pathogen receptor through the recognition of glycan motifs by its three carbohydrate r...

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