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Native Desorption Electrospray Ionization Liberates Soluble and Membrane Protein Complexes from Surfaces

Archive ouverte | Ambrose, Stephen | CCSD

International audience. Mass spectrometry (MS) applications for intact protein complexes typically require electrospray(ES) ionization and have not been achieved via direct desorption from surfaces.D esorption ES io...

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

Archive ouverte | Mehmood, Shahid | CCSD

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A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

Archive ouverte | Pye, Valerie | CCSD

International audience. The human integral membrane protein SERINC5 potently restricts HIV-1 infectivity and sensitizes the virus to antibody-mediated neutralization. Here, using cryo-EM, we determine the structures...

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