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Differential entry of Botulinum Neurotoxin A into neuronal and intestinal cells: an ultrastructural approach

Archive ouverte | Couesnon, Aurélie | CCSD

International audience. Recombinant C-terminus (Hc) of botulinum neurotoxin A (BoNT/A) was used to monitor toxin entry into NG108-15 neuronal cells and m-ICcl2 intestinal cells by both fluorescence and electronic mi...

Translocation and dissemination to target neurons of botulinum neurotoxin type B in the mouse intestinal wall

Archive ouverte | Connan, Chloé | CCSD

International audience. Botulinum neurotoxins (BoNTs) are responsible for severe flaccid paralysis (botulism), which in most cases enter the organism via the digestive tract and then disseminate into the blood or ly...

Pinnatoxins A and G potently and reversibly block transmission at the skeletal neuromuscular junction in vivo and in vitro

Archive ouverte | Benoit, Evelyne | CCSD

International audience. The dinoflagellate Vulcanodinium rugosum, first isolated from Ingril, a French Mediterranean lagoon, is known to produce the pinnatoxins (PnTXs) and the portimines. PnTXs (A-H) constitute an ...

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