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Chromogranin A preferential interaction with Golgi phosphatidic acid induces membrane deformation and contributes to secretory granule biogenesis

Archive ouverte | Carmon, Ophélie | CCSD

International audience. Chromogranin A (CgA) is a key luminal actor of secretory granule biogenesis at the trans‐Golgi network (TGN) level but the molecular mechanisms involved remain obscure. Here, we investigated ...

Phospholipase D1-generated phosphatidic acid modulates secretory granule trafficking from biogenesis to compensatory endocytosis in neuroendocrine cells

Archive ouverte | Tanguy, Emeline | CCSD

International audience. Calcium-regulated exocytosis is a multi-step process that allows specialized secretory cells to release informative molecules such as neurotransmitters, neuropeptides, and hormones for interc...

Chromogranins as molecular coordinators at the crossroads between hormone aggregation and secretory granule biogenesis

Archive ouverte | Carmon, Ophélie | CCSD

International audience

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