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Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions

Archive ouverte | Miserey-Lenkei, Stephanie | CCSD

International audience. The actin and microtubule cytoskeletons play important roles in Golgi structure and function, but how they are connected remain poorly known. In this study, we investigated whether RAB6 GTPas...

A phosphorylation switch regulates RAB6 function during mitosis

Archive ouverte | Jimenez, Ana Joaquina | CCSD

International audience. Abstract RAB GTPases are key regulators of membrane trafficking in eukaryotic cells. In addition to their role in interphase, several RAB proteins, including Golgi-associated RAB6, have mitot...

RAB6 and dynein drive post-Golgi apical transport to prevent neuronal progenitor delamination

Archive ouverte | Brault, Jean‐baptiste | CCSD

International audience. Radial glial (RG) cells are the neural stem cells of the developing neocortex. Apical RG (aRG) cells can delaminate to generate basal RG (bRG) cells, a cell type associated with human brain e...

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