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Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway

Archive ouverte | Lerche, Martina | CCSD

Cells sense and respond to the extracellular matrix (ECM) milieu through integrin proteins. Integrin availability on the plasma membrane, regulated by endosomal receptor uptake and recycling, has been extensively studied and regul...

A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites

Archive ouverte | Mccormick, Barry | CCSD

International audience. Neutrophils are abundant circulating leukocytes that are rapidly recruited to sites of inflammation in an integrin-dependent fashion. Contrasting with the well-characterized regulation of int...

ProLIF – quantitative integrin protein–protein interactions and synergistic membrane effects on proteoliposomes

Archive ouverte | de Franceschi, Nicola | CCSD

International audience. Integrin transmembrane receptors control a wide range of biological interactions by triggering the assembly of large multiprotein complexes at their cytoplasmic interface. Diverse methods hav...

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