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Heart rate influences on repolarization duration and morphology in symptomatic versus asymptomatic KCNQ1 mutation carriers

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Extramiana, Fabrice | Denjoy, Isabelle | Badilini, Fabio | Chabani, Iheb | Neyroud, Nathalie | Berthet, Myriam | Fressard, Véronique | Guicheney, Pascale | Beaufils, Philippe | Leenhardt, Antoine | Coumel, Philippe | Maison-Blanche, Pierre

Edité par CCSD ; Elsevier -

International audience. QT and Tp/Te intervals were longer in patients with LQT1 (n = 67) than in nonaffected subjects (n = 52) but did not differentiate symptomatic (n = 21) from asymptomatic patients (n = 46). At fast heart rate, the time to accumulate the last part of total T-wave area (the t50-97 interval) was longer in symptomatic carriers compared with asymptomatic patients (119 +/- 19 vs 106 +/- 15 ms, p <0.01). The latter group had significantly longer t50-97 intervals than nonaffected subjects (96 +/- 14 ms, p <0.01).

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