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Archive ouverte | Di Pietro, Attilio | CCSD

International audience. MRP1 overexpression in multidrug-resistant cancer cells has been shown to be responsible for collateral sensitivity to some flavonoids that stimulate a huge MRP1-mediated GSH efflux. This mas...

Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1

Archive ouverte | Nasr, Rachad | CCSD

International audience. The transporter Multidrug Resistance Protein 1 (MRP1, ABCC1) is implicated in multidrug resistant (MDR) phenotype of cancer cells. Glutathione (GSH) plays a key role in MRP1 transport activit...

2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2

Archive ouverte | Baiceanu, Elisabeta | CCSD

International audience

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