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Synthesis of novel detergents for extraction and stabilization of membrane proteins and synthesis of aurone derivatives as abcc2 inhibitors. Synthèse de nouveaux détergents extractants et stabilisants des protéines membranaireset synthèse de dérivés d'aurones comme inhibiteurs d'ABCC2

Archive ouverte | Nguyen, Kim-Anh | CCSD

Understanding of tridimensional structure of membrane proteins (MPs) is crucial in medicinal chemistry and biochemistry. To maintain them in solution and consequently to prevent them from aggregation for structural and functional ...

The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead

Archive ouverte | Nguyen, Kim-Anh | CCSD

International audience. The iron-dependent, non-apoptotic cell death, known as ferroptosis is an emerging strategy for the development of anticancer drugs. RSL3 was identified as an activator of ferroptosis through ...

Ovarian cancer cells cisplatin sensitization agents selected by mass cytometry target ABCC2 inhibition

Archive ouverte | Comsa, Elisabeta | CCSD

International audience. Aim: Cisplatin resistance in ovarian cancer remains a complex problem as tumors frequently develop resistance against drugs, a mechanism sometimes mediated by ATP-Binding Cassette transporter...

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