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The integration machinery of ZAM, a retroelement from Drosophila melanogaster, acts as a sequence-specific endonuclease.

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Leblanc, Pascal | Dastugue, B. | Vaury, C.

Edité par CCSD ; American Society for Microbiology -

International audience. Retroviruses and retrotransposons insert into the host genome with no obvious sequence specificity. We examined the target sites of the retroelement ZAM by sequencing each host-ZAM junction in the genome of Drosophila melanogaster. Our overall data provide compelling evidence that ZAM integration machinery recognizes and leads to ZAM insertion into the sequence 5'-GCGCGCg-3'. This unique property of ZAM will facilitate the development of new tools to study the integration process of retroelements.

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