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Removal of Mannose-Ending Glycan at Asn 2118 Abrogates FVIII Presentation by Human Monocyte-Derived Dendritic Cells

Archive ouverte | Delignat, Sandrine | CCSD

International audience. The development of an immune response against therapeutic factor VIII is the major complication in hemophilia A patients. Oligomannose carbohydrates at N239 and/or N2118 on factor VIII allow ...

Inhibitor Formation in Congenital Hemophilia A: an Immunological Perspective

Archive ouverte | Delignat, Sandrine | CCSD

International audience. Hemophilia A (HA) is an X-linked inherited disorder caused by a defect in the gene encoding coagulation factor VIII (FVIII). The disease is typically divided in three categories of severity b...

Prevention of the anti-factor VIII memory B-cell response by inhibition of the Bruton's tyrosine kinase in experimental hemophilia A

Archive ouverte | Delignat, Sandrine | CCSD

International audience. Hemophilia A is a rare hemorrhagic disorder due to the lack of functional pro-coagulant factor VIII. Factor VIII replacement therapy in patients with severe hemophilia A results in the develo...

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