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Dopamine and noradrenaline modulation of goal-directed behavior in orbital and medial prefrontal cortex: Toward a division of labor?

Archive ouverte | Cerpa, Juan-Carlos | CCSD

International audience. The prefrontal cortex is considered to be at the core of goal-directed behaviors. Notably, the medial prefrontal cortex (mPFC) is known to play an important role in learning action-outcome (A...

Targeting Catecholaminergic Systems in Transgenic Rats With a CAV-2 Vector Harboring a Cre-Dependent DREADD Cassette

Archive ouverte | Salafranque, Yoan | CCSD

International audience. Techniques that allow the manipulation of specific neural circuits have greatly increased in the past few years. DREADDs (Designer receptors exclusively activated by designer drugs) provide a...

Noradrenergic signaling in the rodent orbitofrontal cortex is required to update goal-directed actions

Archive ouverte | Cerpa, Juan-Carlos | CCSD

SUMMARY In a constantly changing environment, organisms must track the current relationship between actions and their specific consequences and use this information to guide decision-making. Such goal-directed behavior relies on c...

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