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Mechanistic insights into cellular alteration of prion by poly-D-lysine: the role of H2H3 domain.

Archive ouverte | Xu, Zhou | CCSD

International audience. Misfolding of the prion protein (PrP) is the central feature of prion diseases. The conversion of the normal α-helical PrP(C) into a pathological β-enriched PrP(Sc) constitutes an early event...

The oligomerization properties of prion protein are restricted to the H2H3 domain.

Archive ouverte | Chakroun, Nesrine | CCSD

International audience. The propensity of the prion protein (PrP) to adopt different structures is a clue to its pathological behavior. The determination of the region involved in the PrP(C) to PrP(Sc) conversion is...

Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein.

Archive ouverte | Cavaliere, Paola | CCSD

International audience. Neurodegenerative protein misfolding diseases, including prionopathies, share the common feature of accumulating specific misfolded proteins, with a molecular mechanism closely related. Misfo...

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