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c-Jun/p38MAPK/ASIC3 pathways specifically activated by nerve growth factor through TrkA are crucial for mechanical allodynia development

Archive ouverte | Chaumette, Tanguy | CCSD

International audience. Mechanical allodynia is a cardinal sign of several inflammatory pain disorders where Nerve Growth Factor, a prototypic neurotrophin, plays a crucial role by binding to TrkA receptors. Here, w...

Involvement of toll-like receptor 5 on mouse model of colonic hypersensitivity induced by neonatal maternal separation

Archive ouverte | Mallaret, Geoffroy | CCSD

International audience. Background: Chronic abdominal pain is the most common cause for gastroenterology consultation and is frequently associated with functional gastrointestinal disorders including irritable bowel...

Adherent-Invasive E. coli enhances colonic hypersensitivity and P2X receptors expression during post-infectious period

Archive ouverte | Lashermes, Amandine | CCSD

International audience. Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) are related gastrointestinal disorders characterized by abdominal pain associated with colonic hypersensitivity (CHS). Stud...

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