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Functional Heterogeneity of Mammalian IFITM Proteins against HIV-1

Archive ouverte | Marziali, Federico | CCSD

International audience. Interferon-induced transmembrane proteins (IFITMs) are a family of interferon-inducible proteins that inhibit a broad range of viruses by interfering with viral-to-cellular membrane fusion. T...

Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs

Archive ouverte | Tartour, Kevin | CCSD

International audience. IFITMs are broad antiviral factors that block incoming virions in endosomal vesicles, protecting target cells from infection. In the case of HIV-1, we and others reported the existence of an ...

IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity

Archive ouverte | Tartour, Kevin | CCSD

International audience. BACKGROUND: Interferon induced transmembrane proteins 1, 2 and 3 (IFITMs) belong to a family of highly related antiviral factors that have been shown to interfere with a large spectrum of vir...

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