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Metabolically stable neurotensin analogs exert potent and long-acting analgesia without hypothermia

Archive ouverte | Vivancos, Mélanie | CCSD

International audience. The endogenous tridecapeptide neurotensin (NT) has emerged as an important inhibitory modulator of pain transmission, exerting its analgesic action through the activation of the G protein-cou...

Pain relief devoid of opioid side effects following central action of a silylated T neurotensin analog

Archive ouverte | Tétreault, Pascal | CCSD

International audience. Neurotensin (NT) exerts naloxone-insensitive antinociceptive action through its binding to both NTS 1 and NTS 2 receptors and NT analogs provide stronger pain relief than morphine on a molecu...

Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia

Archive ouverte | Previti, Santo | CCSD

International audience. Therapeutic hypothermia represents a brain-protective strategy for multiple emergencysituations, such as stroke or traumatic injury. Neurotensin (NT), which exerts itseffects through activati...

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