Suggestions

Du même auteur

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

Archive ouverte | Naret, Timothée | CCSD

International audience. We report the synthesis and metabolic and biological evaluation of a series of 17 novel heterocyclic derivatives of isocombretastatin-A4 (iso-CA-4) and their structure-activity relationships....

Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors

Archive ouverte | Hauguel, Camille | CCSD

International audience. A series of quinoline and quinazoline analogs were designed and synthesized as new tubulin polymerization (TP) and histone deacetylases (HDAC) inhibitors. Compounds 12a and 12d showed the bes...

Overcoming Solubility Challenges: Liposomal isoCoQ‐Carbazole as a Promising Anti‐Tumor Agent for Inoperable and Radiation‐Insensitive cancers

Archive ouverte | Lamaa, Diana | CCSD

International audience. Abstract This study evaluated the potential of iso CoQ‐Carbazole, a diheterocyclic analog of iso CA‐4, as an anti‐tumor agent. To overcome its low aqueous solubility, liposomes were developed...

Chargement des enrichissements...