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Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code

Archive ouverte | Rozov, Alexey | CCSD

International audience. Posttranscriptional modifications at the wobble position of transfer RNAs play a substantial role in deciphering the degenerate genetic code on the ribosome. The number and variety of modific...

Structural insights into the translational infidelity mechanism

Archive ouverte | Rozov, Alexey | CCSD

International audience. The decoding of mRNA on the ribosome is the least accurate process during genetic information transfer. Here we propose a unified decoding mechanism based on 11 high-resolution X-ray structur...

The ribosome prohibits the G•U wobble geometry at the first position of the codon–anticodon helix

Archive ouverte | Rozov, Alexey | CCSD

International audience. Precise conversion of genetic information into proteins is essential to cellular health. However, a margin of error exists and is at its highest on the stage of translation of mRNA by the rib...

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