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Human Dicer helicase domain recruits PKR and dsRNA binding proteins during viral infection

Archive ouverte | Montavon, Thomas | CCSD

The antiviral innate immune response mainly involves type I interferon (IFN) in mammalian cells. The contribution of the RNA silencing machinery remains to be established, but several recent studies indicate that the ribonuclease ...

Proteomics-based determination of double-stranded RNA interactome reveals known and new factors involved in Sindbis virus infection

Archive ouverte | Girardi, Erika | CCSD

International audience. Viruses are obligate intracellular parasites, which depend on the host cellular machineries to replicate their genome and complete their infectious cycle. Long double-stranded (ds)RNA is a co...

Human DICER helicase domain recruits PKR and modulates its antiviral activity

Archive ouverte | Montavon, Thomas | CCSD

The antiviral innate immune response mainly involves type I interferon (IFN) in mammalian cells. The contribution of the RNA silencing machinery remains to be established, but several recent studies indicate that the ribonuclease ...

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