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A conserved uORF impacts APOBEC3G translation and is essential for translational inhibition by the HIV-1 Vif protein

Archive ouverte | Libre, Camille | CCSD

ABSTRACT The HIV-1 Vif protein is essential for viral fitness and pathogenicity. Vif decreases expression of cellular cytosine deaminases APOBEC3G (A3G), A3F, A3D and A3H, which inhibit HIV-1 replication by inducing hypermutations...

A Conserved uORF Regulates APOBEC3G Translation and Is Targeted by HIV-1 Vif Protein to Repress the Antiviral Factor

Archive ouverte | Libre, Camille | CCSD

International audience. The HIV-1 Vif protein is essential for viral fitness and pathogenicity. Vif decreases expression of cellular restriction factors APOBEC3G (A3G), A3F, A3D and A3H, which inhibit HIV-1 replicat...

APOBEC3F/G and Vif: Action and Counteractions

Archive ouverte | Libre, Camille | CCSD

International audience

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