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G6PD protects from oxidative damage and improves healthspan in mice

Archive ouverte | Nobrega-Pereira, Sandrina | CCSD

Reactive oxygen species (ROS) are constantly generated by cells and ROS-derived damage contributes to ageing. Protection against oxidative damage largely relies on the reductive power of NAPDH, whose levels are mostly determined b...

Overexpression of G6PD as a model of robustness

Archive ouverte | Arc-Chagnaud, Coralie | CCSD

Frailty is a major geriatric syndrome that has been associated to oxidative stress. The antioxidant system is largely based on the reducing power of NADPH, whose levels are mainly determined by the enzyme glucose-6-phosphate dehyd...

Glucose 6‐P dehydrogenase delays the onset of frailty by protecting against muscle damage

Archive ouverte | Arc-Chagnaud, Coralie | CCSD

International audience. Background Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on r...

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